Cabozantinib hydrochloride ( XL184 | BMS-907351 )

Catalog No. M19952 CAS No. ——

Cabozantinib (XL184) is a potent pan-tyrosine kinases inhibitor that inhibits VEGFR2 c-Met Kit Axl and Flt4 (IC50s: 0.035 1.3 4.6 7 and 6 nM).

Purity : >98% (HPLC)

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

Size	Price / USD	Stock	Quantity
2MG	49	Get Quote
5MG	70	Get Quote
10MG	108	Get Quote
25MG	188	Get Quote
50MG	283	Get Quote
100MG	Get Quote	Get Quote
200MG	Get Quote	Get Quote
500MG	Get Quote	Get Quote
1G	Get Quote	Get Quote

Get Quotation Bulk Inquiry Add to Cart

Biological Information

Product Name

Cabozantinib hydrochloride
Note

Research use only, not for human use.
Brief Description

Cabozantinib (XL184) is a potent pan-tyrosine kinases inhibitor that inhibits VEGFR2 c-Met Kit Axl and Flt4 (IC50s: 0.035 1.3 4.6 7 and 6 nM).
Description

Cabozantinib (XL184) is a potent pan-tyrosine kinases inhibitor that inhibits VEGFR2 c-Met Kit Axl and Flt4 (IC50s: 0.035 1.3 4.6 7 and 6 nM).
In Vitro

——
In Vivo

——
Synonyms

XL184 | BMS-907351
Pathway

Angiogenesis
Target

c-Met/HGFR
Recptor

c-Kit| c-Met| VEGFR2/KDR| FLT4| Axl|RORγ|RORα
Research Area

Cancer
Indication

Adrenocortical carcinoma; Bone metastases; Brain metastases; Breast Cancer; Cholangiocarcinoma; Endometrial Cancer; Ewing's sarcoma

Chemical Information

CAS Number

——
Formula Weight

537.96
Molecular Formula

C28H25ClFN3O5
Purity

>98% (HPLC)
Solubility

DMSO: 80 mg/mL
SMILES

Cl.COc1cc2nccc(Oc3ccc(NC(=O)C4(CC4)C(=O)Nc4ccc(F)cc4)cc3)c2cc1OC
Chemical Name

——

Shipping & Storage Information

Storage

(-20℃)
Shipping

With Ice Pack
Stability

≥ 2 years

Reference

1.Yakes FM et al. Cabozantinib (XL184) a novel MET and VEGFR2 inhibitor simultaneously suppresses metastasis angiogenesis and tumor growth. Mol Cancer Ther 2011 10(12) 2298-2308.

Calculator

Molecular Weight Calculator

Dilution Calculator

Molarity Calculator

molnova catalog

Product			Quantity Required*
Name *			E-mail Address *
Organization *			Phone Number
Remarks